Overview
- Brings together a thorough collection of cutting-edge methods for protein folding and misfolding
- Features concise, step-by-step approaches to the varying topics
- Includes key tips and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 752)
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Table of contents (15 protocols)
Keywords
About this book
Protein misfolding is a key feature of many disorders in humans, given that over twenty proteins are known to misfold and cause disease. In Protein Folding, Misfolding, and Disease: Methods and Protocols, experts in the field present a collection of current methods for studying the analysis of protein folding and misfolding, featuring strategies for expressing and refolding recombinant proteins which can then be utilized in subsequent experiments. This detailed volume also covers methods for analyzing the formation of amyloid, protocols for determining the size and structure of native and misfolded proteins, as well as specific examples of where misfolded proteins can be examined using state-of –the-art technologies. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Up to date and authoritative, Protein Folding, Misfolding, and Disease: Methods and Protocols offers researchers the tools necessary to move ahead in this vital field.
Editors and Affiliations
Bibliographic Information
Book Title: Protein Folding, Misfolding, and Disease
Book Subtitle: Methods and Protocols
Editors: Andrew F. Hill, Kevin J. Barnham, Stephen P. Bottomley, Roberto Cappai
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60327-223-0
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-60327-221-6Published: 01 July 2011
Softcover ISBN: 978-1-4939-5689-0Published: 23 August 2016
eBook ISBN: 978-1-60327-223-0Published: 29 June 2011
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: X, 249
Topics: Protein Science, Pathology